Qualitative Histological Analysis of Adrenal Cortex Following Application of Medroxyprogesterone Acetate
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چکیده
Material and Methods. Total of 48 female Wistar rats were divided into four groups. Control group was given saline daily, intra-muscularly, and the other three groups MPA in doses of 7.5, 15.0 and 75.0 mg/kg bw during 30 days. Paraffin sections from adrenal glands were stained according the following methods: hematoxylin-eosin, Azan modified by Heidenhein, Van-Gieson, Kossa-Goldner, Masson and Florentin.
منابع مشابه
Quantitative Analysis of Adrenal Cortical Histological Alterations After Application of Medroxyprogesterone Acetate
Results. Gravimetric and variance analysis demonstrated the most remarkable decrease of the adrenal gland weight after the application of 75.0 mg/kg/bw MPA (from 35.66 ± 11.78 to 13.41 ± 8.41 mg (p<0.001). On the other hand, morphometric analysis demonstrated that adrenal cortex volume was the most significantly reduced from 11.30 ± 3.53 in the control group to 2.04 ± 0.90 mm3 in the group trea...
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